Being positive in life and also applying positive charge on wound is good – wonder why?

20.4.2021

Almost everyone in their lives had someone said to them to be positive, to always look on the bright side.

But, what if you apply positivity, or in this case, positive charge as a part of a wound dressing? Crazy? Probably not, and maybe you’ll understand better little bit later.

A lot of money is spent annually on wound dressings in general (approximately €6.5 billion in Europe for treating one type of wound1). But, even when the wound dressing is applied, sometimes the wound takes longer time to heal. It depends on the patient, if it has a preexisting condition such as high sugar levels. Also, if the wound is not covered, dust, dirt, chemicals, or other external impacts can have the similar impact prolonging the healing of the wound. The main cause of each of the situations is the involvement of the microbes, bacteria specifically. This causes the inflammation of the wound, and if it is not treated properly, the wound can become chronic, and will not heal accordingly.

So… why positive charge?

Well, it is known already that the membrane of the bacteria is negatively charged. Positively charged materials which are then applied, is causing the death of the bacteria. The caption below shows the way how it is done. Material and the membrane of the bacteria is creating the ionic bonding between each other, which allows the positively charged molecule to insert itself in the membrane and breaking it. Inside material of the bacteria (cytosol, plasmide…) leaks out, and leads to death of the bacteria.

 

By chemically bonding the cationic molecules onto natural sugars such as starch, cellulose, dextrane, chitosan… it creates a possibility that with different methods, production of a material to be used as a wound dressing is manageable.

So, if positively charged wound dressing is produced, then this material is not only used as a protection from dirt, dust and other external impacts, but also protects the wound from bacteria and similar microorganisms.

So… in general, it is not only important to just have positive outlook on life, but also positive charge can have a good impact on wound healing itself.

 

References:
1 
Harding, K. (2015). Innovation and Wound Healing. Journal of Wound Care, 24(Sup4b), 7–13; 
Mortazavian, Hamid, Leanna Foster, Rajani Bhat, Shyrie Patel, and Kenichi Kuroda. "Decoupling the Functional Roles of Cationic and Hydrophobic Groups in the Antimicrobial and Hemolytic Activities of Methacrylate Random Copolymers." Biomacromolecules 19 (10/15 2018).

 

Writer:

Lujica Jurko

ESR14 - University of Maribor